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  • ContentsContents
  • Article InfoArticle Info
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  • FigsFigs
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  • DataData
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  • CitedCited
  • Article title
  • Abstract
  • Key words
  • Introduction
  • Methods and materials
    • General experimental procedures
    • Fungal material and taxonomy
      • Sample collection and morphological characterization
      • Sequence alignments and phylogenetic analyses
    • Fermentation, extraction, and isolation
      • Rice fermentation
      • Liquid fermentation of potato dextrose broth (PDB)
      • Liquid fermentation of glucose peptone yeast (GPY)
    • Calculations of 13C NMR, ECD, and optical rotation
    • Bioassays
      • Assays of immunosuppressive activity, lymphocyte viability, and antiproliferative activity against HaCaT cells
      • Cytokine analysis by ELISA of induced T cells
      • EdU proliferation assay
    • Immunofluorescence protocol (cell climbing slides)
    • Statistics and reproducibility
      • Spectroscopic data of compounds
      • 11α,16-Epoxy-isopimar-8(9)-en-19β-oic acid (1)
      • 16-α-D-Mannopyranosyloxyisopimar-8(9)-en-19-oic acid (2)
      • 16-α-D-Glucopyranosyloxyisopimar-8(9)-en-19-oic acid (3)
      • Cyclo(L-Phe-L-Val-D-Ile-L-Leu-L-Pro) (4)
      • Diplosporin A (5)
      • Diplosporin B (6)
      • Diplosporin C (7)
      • Diplosporin D (8)
      • Diplosporin E (9)
      • Diplosporin F (10)
      • Diplosporin G (11)
      • Diplosporin H (12)
      • Diplosporin I (13)
      • (R)-8-methoxy-3-(methoxymethyl)isochroman-1-one (14)
  • Results and discussion
    • Identification of the strain
    • Structure elucidation of previously undescribed fungal metabolites (1–14)
    • Empirical rules for the configuration of 6-ethyl-5,6,7,8-tetrahydro-4H-chromen-4-one
    • Biological properties
    • Analysis of the structure-activity relationship
  • Conclusion
  • Additional information
    • Conflict of interest
    • Ethical statement
    • Use of AI
    • Adherence to national and international regulations
    • Funding
    • Author contributions
    • Author ORCIDs
    • Data availability
  • References
  • Supplementary material
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