The Fungi-specific histone Acetyltransferase Rtt109 mediates morphogenesis, Aflatoxin synthesis and pathogenicity in Aspergillus flavus by acetylating H3K9

Shihua Wang; Meifang Wen; Lianghuan Wu; Huahui Lan; Jun Yuan; Shihua Wang

doi:10.1186/s43008-021-00060-4

Yanjie Yi, Rumeng Liu, Zijun Shang, Kai Wang, Changfu Zhang, Zihao Wang, Yu Lou, Jiaoyang Liu, Peng Li (2025)
Peppermint Essential Oil For Controlling Aspergillus flavus and Analysis of its Antifungal Action Mode. Current Microbiology 82: .

DOI: 10.1007/s00284-025-04116-1

Xuan Chen, Lihan Wu, Yuqi Zhang, Sen Wang, Shihua Wang, Richard Gerald Brennan (2025)
Importance of benzoyltransferase GcnE and lysine benzoylation of alcohol dehydrogenase AdhB in pathogenesis and aflatoxin production in Aspergillus flavus . mBio 16: .

DOI: 10.1128/mbio.02665-24

Dalang Yu, Zhiping Liu (2022)
The research progress in the interaction between Candida albicans and cancers. Frontiers in Microbiology 13: .

DOI: 10.3389/fmicb.2022.988734

Kunlong Yang, Jun Tian, Nancy P. Keller (2022)
Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review. Environmental Microbiology 24: 2857.

DOI: 10.1111/1462-2920.16034

Jan Breuer, David Emanuel Antunes Ferreira, Mike Kramer, Jonas Bollermann, Minou Nowrousian, J Dunlap (2024)
Functional analysis of chromatin-associated proteins in Sordaria macrospora reveals similar roles for RTT109 and ASF1 in development and DNA damage response. G3: Genes, Genomes, Genetics 14: .

DOI: 10.1093/g3journal/jkae019

Nubia Andrea Villota-Salazar, Víctor Hugo Ramos-García, Juan Manuel González-Prieto, Sanjuana Hernández-Delgado (2023)
Effects of chemical inhibition of histone deacetylase proteins in the growth and virulence of Macrophomina phaseolina (Tassi) Goid.. Revista Argentina de Microbiología 55: 296.

DOI: 10.1016/j.ram.2023.04.002

Xiaokang Zhang, Yuzhu Zhou, Yangzhi Liu, Boqiang Li, Shiping Tian, Zhanquan Zhang (2024)
Research Progress on the Mechanism and Function of Histone Acetylation Regulating the Interaction between Pathogenic Fungi and Plant Hosts. Journal of Fungi 10: 522.

DOI: 10.3390/jof10080522

Betim Karahoda, Brandon T. Pfannenstiel, Özlem Sarikaya-Bayram, Zhiqiang Dong, Koon Ho Wong, Alastair B. Fleming, Nancy P. Keller, Özgür Bayram (2023)
The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus. Fungal Genetics and Biology 169: 103836.

DOI: 10.1016/j.fgb.2023.103836

Ruoyu Shi, Pengfei Gong, Qiaoqiao Luo, Wei Chen, Chengtao Wang (2023)
Histone Acetyltransferase Rtt109 Regulates Development, Morphogenesis, and Citrinin Biosynthesis in Monascus purpureus. Journal of Fungi 9: 530.

DOI: 10.3390/jof9050530

Yiling Lai, Lili Wang, Weilu Zheng, Sibao Wang (2022)
Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens. Journal of Fungi 8: 565.

DOI: 10.3390/jof8060565

Andreas Schüller, Lena Studt-Reinhold, Joseph Strauss (2022)
How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances. Pharmaceutics 14: 1837.

DOI: 10.3390/pharmaceutics14091837

Hang Jiang, Lifang Yuan, Liguo Ma, Kai Qi, Yueli Zhang, Bo Zhang, Guoping Ma, Junshan Qi (2024)
Histone H3 N-Terminal Lysine Acetylation Governs Fungal Growth, Conidiation, and Pathogenicity through Regulating Gene Expression in Fusarium pseudograminearum. Journal of Fungi 10: 379.

DOI: 10.3390/jof10060379

Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang (2022)
Potential antifungal targets based on histones post-translational modifications against invasive aspergillosis. Frontiers in Microbiology 13: .

DOI: 10.3389/fmicb.2022.980615

Xiaohua Pan, Ling Hao, Chi Yang, Hong Lin, Dandan Wu, Xuan Chen, Mengjuan Zhang, Dongmei Ma, Yu Wang, Wangzhuo Fu, Yanfang Yao, Shihua Wang, Zhenhong Zhuang (2023)
SWD1 epigenetically chords fungal morphogenesis, aflatoxin biosynthesis, metabolism, and virulence of Aspergillus flavus. Journal of Hazardous Materials 455: 131542.

DOI: 10.1016/j.jhazmat.2023.131542

Yinhui Jiang, Xiang Liu, Xun Tian, Jianhong Zhou, Qinrong Wang, Bi Wang, Wenfeng Yu, Yanping Jiang, Tom Hsiang, Xiaolan Qi (2023)
RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection. Frontiers in Microbiology 14: .

DOI: 10.3389/fmicb.2023.1252294

Xuwen Hou, Liyao Liu, Yu Li, Pengfei Wang, Xiaoqian Pan, Dan Xu, Daowan Lai, Ligang Zhou (2024)
Regulation of Histone Acetylation Modification on Biosynthesis of Secondary Metabolites in Fungi. International Journal of Molecular Sciences 26: 25.

DOI: 10.3390/ijms26010025

Haoyun Song, Rong Shen, Xiangwen Liu, Xuguang Yang, Kun Xie, Zhao Guo, Degui Wang (2023)
Histone post-translational modification and the DNA damage response. Genes & Diseases 10: 1429.

DOI: 10.1016/j.gendis.2022.04.002

Anna Katharina Atanasoff-Kardjalieff, Lena Studt (2022)
Secondary Metabolite Gene Regulation in Mycotoxigenic Fusarium Species: A Focus on Chromatin. Toxins 14: 96.

DOI: 10.3390/toxins14020096

Aurelie Etier, Fabien Dumetz, Sylvain Chéreau, Nadia Ponts (2022)
Post-Translational Modifications of Histones Are Versatile Regulators of Fungal Development and Secondary Metabolism. Toxins 14: 317.

DOI: 10.3390/toxins14050317

Liuke Liang, Xiaoyan Wang, Haier Lan, Shan Wei, Yang Lei, Shuaibing Zhang, Huanchen Zhai, Yuansen Hu, Yangyong Lv (2024)
Comprehensive analysis of aflatoxin B1 biosynthesis in Aspergillus flavus via transcriptome-wide m6A methylome response to cycloleucine. Journal of Hazardous Materials 461: 132677.

DOI: 10.1016/j.jhazmat.2023.132677

Zhenghua Chai, Yanjian Li, Jing Zhang, Chen Ding, Xiujuan Tong, Zhijie Zhang, Alexandre Alanio (2024)
Sirtulin–Ypk1 regulation axis governs the TOR signaling pathway and fungal pathogenicity in Cryptococcus neoformans . Microbiology Spectrum 12: .

DOI: 10.1128/spectrum.00038-24

Wenjie Wang, Xinle Liang, Yudong Li, Pinmei Wang, Nancy P. Keller (2022)
Genetic Regulation of Mycotoxin Biosynthesis. Journal of Fungi 9: 21.

DOI: 10.3390/jof9010021

Lynise C. Pillay, Lucpah Nekati, Phuti J. Makhwitine, Sizwe I. Ndlovu (2022)
Epigenetic Activation of Silent Biosynthetic Gene Clusters in Endophytic Fungi Using Small Molecular Modifiers. Frontiers in Microbiology 13: .

DOI: 10.3389/fmicb.2022.815008

Yamei Wang, Jialu Fan, Zhengyu Zhou, Gustavo H. Goldman, Ling Lu, Yuanwei Zhang, Yvonne Nygård (2024)
Histone acetyltransferase Sas3 contributes to fungal development, cell wall integrity, and virulence in Aspergillus fumigatus . Applied and Environmental Microbiology 90: .

DOI: 10.1128/aem.01885-23

Man Chen, Yuanli Liu, Zhuozhuo Liu, Lin Su, Lili Yan, Yuan Huang, Ye Huang, Wei Zhang, Xinping Xu, Fanglin Zheng, Aaron P. Mitchell (2023)
Histone acetyltransferase Gcn5-mediated histone H3 acetylation facilitates cryptococcal morphogenesis and sexual reproduction. mSphere 8: .

DOI: 10.1128/msphere.00299-23